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enquirebio 6659-MSM1-P0说明书

 更新时间:2020-04-28 点击量:473

enquirebio 6659-MSM1-P0说明书

SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 199.00 – $ 429.00

 

Product NumberDescriptionPrice
6659-MSM1-P0Size: 20 ug, Tag: Unconjugated$ 199.00
6659-MSM1-P1Size: 100 ug, Tag: Unconjugated$ 429.00
6659-MSM1-P1ABXSize: 100 ug, Tag: Unconjugated$ 429.00


SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540).Confirmation of Integrity and Purity of Antibody.

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SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540).Confirmation of Integrity and Purity of Antibody.

Analysis of Protein Array containing more than 19,000 full-length human proteins using SOX4 Mouse Monoclonal Antibody (SOX4/2540).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).

 

人抗SOX4(上皮-间质转化的主调节剂)抗体产品属性

物种:人类

经过测试的应用程序: IHC。

克隆性:单克隆

抗SOX4(上皮-间质转化的主调节剂)抗体克隆:SOX4 / 2540

克隆SOX4 / 2540宿主和同种型:小鼠IgG2b,κ

抗人类SOX4(上皮-间质转化的主调节剂)阳性对照样品:乳腺癌或结肠癌

SOX4 / 2540抗体染色的细胞定位:

缓冲液和稳定剂: 10mM PBS,含0.05%BSA和0.05%叠氮化物。也可不带BSA和叠氮化物。

抗体浓度: 200 ug / ml

抗体纯化方法:从生物反应器浓缩物中纯化的蛋白A / G。

免疫原:重组全长人SOX4蛋白

储存条件:储存于2至8 C(冷藏)。正确存放后可稳定保存24个月。

SOX4(上皮-间质转化的主要调节剂)以前观察到的抗体染色模式

限制与保证

inquire Bio的产品SOX4(上皮-间质转化的主调节剂)MonoSpecific抗体仅可用于研究用途(仅限于RUO)。正确存放后,保证该抗体可工作两年。

 

SOX4(上皮-间质转化的主调节剂)一般信息
备用名
SOX; SRY(性别确定区域Y)框4;含有基因4的SRY盒;SRY相关的HMG盒基因4;转录因子SOX-4
分子量
47kDa的
染色体位置
在蓝色冰上的船。
精选数据库和生物信息学数据
基因符号6659
Entrez基因IDSOX4
UniProt IDQ06945
UniGene IDHs643910
COSMIC ID链接SOX4
KEGG基因IDhsa:6659
SOX4(上皮-间质转化的主调节剂)的概述。
SOX4是转录因子SOX(与SRY相关的HMG-box)家族的成员,在心脏,胰腺,大脑的器官发生以及B和T淋巴细胞分化过程中,在胚胎发育和细胞命运确定中起关键作用。SOX4基因表达在许多癌症类型中均被上调,并且SOX4活性的增加有助于细胞转化,细胞存活和转移。基因表达谱已经发现在正常和癌性乳腺癌上皮细胞中TGF-β诱导的上皮-间质转化(EMT)期间具有上调活性的SOX4。SOX4对于体外EMT和细胞存活以及体内原发性肿瘤生长和转移是*的。通过控制表观遗传修饰因子Ezh2的表达,SOX4被确定为EMT的主要调控因子。