Protein Name | Species | Fusion Tag | Catalog Code | Interacting Protein(s) |
BAFFR | human | Mouse IgG2a Fc | P7114F | BAFF (P7003M) |
BAFFR | human | His-Flag | P7114M | BAFF (P7003M) |
BAFFR | human | Mouse IgG2a aglyco-Fc | P7114G | BAFF (P7003M) |
BCMA | macaque | Mouse IgG2a Fc | C7011F | BAFF, APRIL |
BCMA | human | Mouse IgG2a Fc | P7011F | BAFF (P7003M), APRIL (P7002F) |
BCMA | human | His-Flag | P7011M | BAFF (P7003M), APRIL (P7002F) |
BCMA | human | Mouse IgG2a aglyco-Fc | P7011G | BAFF (P7003M), APRIL (P7002F) |
CD27 | human | Mouse IgG2a Fc | P7082F | CD27L (P7004F) |
CD40 | human | No Tag | P7015Y | CD40L (P7005F), CD40L (P7005H), CD40L (P7005M), CD40L (P7005Y) |
DcR3 | human | Mouse IgG2a Fc | P7073F | TL1A-S (P7028F), TL1A-L (P7042F), FASL |
DR3 | human | Mouse IgG2a Fc | P7065F | TL1A-S (P7028F), TL1A-L (P7042F) |
DR4 | human | Mouse IgG2a Fc | P7049F | TRAIL (P7008F) |
DR5 | human | Mouse IgG2a Fc | P7053F | TRAIL (P7008F) |
EDAR | human | Mouse IgG2a Fc | P7045F | EDA (P7030F) |
FAS | human | Mouse IgG2a Fc | P7061F | FASL |
GITR | human | Mouse IgG2a Fc | P7035F | GITRL |
GITR | human | Mouse IgG2a aglyco-Fc | P7035G | GITRL |
HVEM | human | Mouse IgG2a Fc | P7076F | LT-a (P7006M), LIGHT, BTLA |
HVEM | human | Mouse IgG2a aglyco-Fc | P7076G | LT-a (P7006M), LIGHT, BTLA |
LTbR | human | Mouse IgG2a Fc | P7079F | LT-α1β2, LIGHT |
NGFR | human | Mouse IgG2a Fc | P7017F | NGF, NTF-3, NTF-4, BDNF |
OPG | human | Mouse IgG2a Fc | P7019F | TRAIL (P7008F), RANKL |
OPG | human | His-Flag-Myc | P7019T | TRAIL (P7008F), RANKL |
OPG | human | Mouse IgG2a aglyco-Fc | P7019G | TRAIL (P7008F), RANKL |
OX40 | human | Mouse IgG2a Fc | P7046F | OX40L |
OX40 | human | Mouse IgG2a aglyco-Fc | P7046G | OX40L |
RANK | human | Mouse IgG2a Fc | P7032F | RANKL |
TACI | human | Mouse IgG2a Fc | P7012F | BAFF (P7003M), APRIL (P7002F) |
TACI | human | Mouse IgG2a aglyco-Fc | P7012G | BAFF (P7003M), APRIL (P7002F) |
TNFR1 | macaque | Mouse IgG2a Fc | C7020F | TNF, LT-a |
TNFR1 | human | Mouse IgG2a Fc | P7020F | TNF (P7113T), TNF (P7113F), TNF (P7113M), LT-a (P7006M) |
TNFR1 | human | Mouse IgG2a aglyco-Fc | P7020G | TNF (P7113T), TNF (P7113F), TNF (P7113M), LT-a (P7006M) |
TNFR2 | human | Mouse IgG2a Fc | P7022F | TNF (P7113T), TNF (P7113F), TNF (P7113M), LT-a (P7006M) |
TNFR2 | human | Mouse IgG2a aglyco-Fc | P7022G | TNF (P7113T), TNF (P7113F), TNF (P7113M), LT-a (P7006M) |
TRAIL-R3 | human | Mouse IgG2a Fc | P7057F | TRAIL (P7008F) |
TRAL-R4 | human | Mouse IgG2a Fc | P7059F | TRAIL (P7008F) |
在人类中,已鉴定出29个TNF受体(TNFR)家族成员。除了少数例外,大多数都是I型膜蛋白。BCMA,BAFFR,TACI和XEDAR都缺乏信号肽,被归类为III型膜蛋白。OPG和DcR3均为可溶蛋白,TRAIL-R3与糖脂一起束缚在膜上。另外,可以将包括CD27,CD30,CD40,TNFR1和TNFR2在内的许多TNFR进行蛋白水解加工成可溶性受体。FAS和4-1BB还可以通过选择性切下跨膜编码外显子来表达为可溶形式。每种都能够与其配体相互作用的可溶性受体显示出可调节各自膜锚定受体的活性。许多TNF受体与一个以上的配体相互作用。这些包括TNFR1和TNFR2与TNF-α和LT-α相互作用,BCMA和TACI均与BAFF和APRIL相互作用,HVEM与LIGHT,LT-α和BTLA相互作用,LTβR与LT-α1β2和LIGHT相互作用,OPG与RANKL和TRAIL相互作用。尚未确定RELT,TRAMP,TROY和DR6的配体。TNFR超家族成员的几乎所有配体均属于TNF超家族(TNFSF)。HVEM和EGFR例外,因为BTLA和NGF / BDNF /神经营养蛋白在结构上与TNFSF蛋白无关。越来越多的分子相互作用和信号传导途径的详细信息已成为许多TNFRSF成员的疾病干预积极研究的目标。TNFR超家族成员的几乎所有配体均属于TNF超家族(TNFSF)。HVEM和EGFR例外,因为BTLA和NGF / BDNF /神经营养蛋白在结构上与TNFSF蛋白无关。越来越多的分子相互作用和信号传导途径的详细信息已成为许多TNFRSF成员的疾病干预积极研究的目标。TNFR超家族成员的几乎所有配体均属于TNF超家族(TNFSF)。HVEM和EGFR例外,因为BTLA和NGF / BDNF /神经营养蛋白在结构上与TNFSF蛋白无关。越来越多的分子相互作用和信号传导途径的详细信息已成为许多TNFRSF成员的疾病干预积极研究的目标。
我们的TNFRSF-Fc融合蛋白是在小鼠IgG2a铰链区通过一对二硫键连接的同型二聚体,经过亲和纯化,大小均一。